Are psychedelics really safe to take as medicine?
It may sound like something from a Timothy Leary dream, but psychedelic therapy using psilocybin, LSD, ketamine, and MDMA is becoming more widely studied -- and advocated -- to improve outcomes of therapy for depression, anxiety, eating disorders, trauma and addiction. One study found that folks with treatment-resistant depression saw sustained improvement for a year after taking two doses of psilocybin. Another study found that the drug significantly relieved symptoms of persistent PTSD.
According to Mass General's McClean Hospital, psychedelics can improve those mental illnesses or disturbances by affecting parts of the brain that respond to the neurotransmitter serotonin, changing a person's emotions and mood. This also allows for new neural connections to be made in the brain, improving thinking patterns.
However, a new position statement by the American Psychiatry Association says, "There is currently inadequate scientific evidence for endorsing the use of psychedelics to treat any psychiatric disorder except within the context of approved investigational studies." And we urge people not to try any of these substances on their own, they can have an unexpected impact on your emotions, with very serious side effects.
If you're interested in trying them to ease treatment-resistant emotional conditions, ask your doctor for information on clinical trials or go to clinicaltrials.gov to view a list of ongoing ones nationally. For example, searching on that site for depression and psilocybin turns up many studies that are currently recruiting participants.
For additional information on how to manage distress, check out our book "You: Stress Less -- The Owner's Manual for Regaining Balance in Your Life."
Dr. Mike Roizen is the founder of www.longevityplaybook.com, and Dr. Mehmet Oz is global advisor to www.iHerb.com, the world's leading online health store. Roizen and Oz are chief wellness officer emeritus at Cleveland Clinic and professor emeritus at Columbia University, respectively. Together they have written 11 New York Times bestsellers (four No. 1's).
(c)2025 Michael Roizen, M.D.
Distributed by King Features Syndicate, Inc.
(c) 2025 Michael Roizen, M.D. Distributed by King Features Syndicate, Inc.
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