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Study shows how cancer gene PTEN works
Researchers at Beth Israel Deaconess Medical Center and the Harvard Medical School said the PTEN tumor suppressor gene controls numerous biological processes including cell proliferation, cell growth and death. But the alteration of the gene is so common among various types of human cancer, PTEN has become one of the most frequently mutated of all tumor suppressors.
"Our laboratory recently discovered that even when PTEN is produced normally by a cell, it has to be properly localized within the nucleus in order to maintain its full tumor suppressive abilities," said Dr. Pier Paolo Pandolfi, senior author of the research. "Indeed, it's been demonstrated that in a variety of cancers, PTEN has broken away from the nucleus. With these new findings, we now understand how this happens."
The study that included researchers Min Sup Song, Leonardo Salmena, Arkaitz Carracedo and Ainara Egia, along with Francesco Lo-Coco of Italy's University of Tor Vergata and Julie Teruya-Feldstein of the Memorial Sloan-Kettering Cancer Center appears in the online edition of the journal Nature.
Copyright 2008 by United Press International
This news arrived on: 08/21/2008
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